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Showing posts from August 2, 2026

Georgia's Leading Children's Hospital and the Eliava Institute Join Forces to Advance Pediatric Phage Therapy

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Georgia has taken another important step toward integrating bacteriophage therapy into modern clinical practice following the signing of a strategic memorandum of cooperation between the M. Iashvili Children's Central Hospital and the George Eliava Institute of Bacteriophages, Microbiology and Virology. More than a symbolic agreement, the partnership brings together the country's largest pediatric referral hospital and one of the world's oldest and most internationally recognized phage research institutions with the shared objective of expanding access to personalized phage therapy for children facing severe bacterial infections. Illustration taken from :  https://medscriptum.org/en/when-innovation-meets-tradition-memorandum-of-cooperation-signed-between-iashvili-clinic-and-the-eliava-institute/ The agreement reflects a broader transformation taking place in infectious disease medicine. As antimicrobial resistance continues to reduce the effectiveness of conventional antib...
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How Can We Protect Bacteriophages Without Trapping Them? Mathematics May Hold the Key to More Effective Oral Phage Therapy

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For more than a century, bacteriophages have fascinated microbiologists because of their remarkable ability to infect and eliminate bacteria with extraordinary specificity. Today, their renaissance is being driven by the global antimicrobial resistance crisis, yet one of the greatest challenges facing phage therapy has surprisingly little to do with virology itself. Even the most potent therapeutic phage becomes ineffective if it cannot survive long enough to reach the infection. This is particularly true for oral administration, where bacteriophages must first pass through the highly acidic gastric environment before reaching the intestine, a journey that destroys a substantial proportion of viral particles before they ever encounter their bacterial host. Protecting phages from this hostile environment has therefore become one of the major engineering problems in modern phage therapy. Encapsulation has emerged as one of the most promising solutions. Instead of administering free phag...
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Most Consulted Articles

Bacteriophages Disarm Inflammation-Associated E. coli Without Erasing the Gut Microbiome in IBD

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Inflammatory bowel disease is usually described through the language of immune dysregulation, chronic inflammation and genetic susceptibility. Yet an increasingly important part of the disease may lie in a more dynamic layer of biology: not simply which microorganisms inhabit the intestine, but what particular bacterial populations are doing inside it. A new study from McMaster University pushes this idea toward a striking therapeutic possibility. Instead of broadly eliminating bacteria associated with disease, bacteriophages may be used to selectively suppress the bacterial traits that help drive inflammation. McMaster researchers, from left, Kyle Jackson, Zeinab Hosseinidoust and Elena Verdu, have found a way to disarm harmful gut bacteria using precision viruses, opening the door to more personalized treatments for inflammatory bowel disease. (Georgia Kirkos, McMaster University) The work, published in Science Translational Medicine and highlighted on the journal’s cover, emerged...
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History Part 12 : Post-War Stagnation and Phage Therapy’s Marginalization in the West (1945–1980s)

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Post-War Stagnation and Phage Therapy’s Marginalization in the West (1945–1980s) The period following World War II marked a decisive turning point in the trajectory of phage therapy in Western medicine. Despite the promising results bacteriophages had demonstrated prior to the war as potential antibacterial agents, the decades after 1945 saw a dramatic decline in interest, funding, and scientific engagement with phage therapy in the United States and much of Western Europe. This marginalization can be attributed to a confluence of scientific, sociopolitical, and economic factors that reshaped the landscape of infectious disease treatment and research. Artistic View One of the key contributors to this decline was the overwhelming optimism surrounding the newly discovered class of antibiotics. The post-war pharmaceutical revolution brought forward a series of broad-spectrum antibiotics such as streptomycin, tetracycline, and chloramphenicol, which were viewed as miracle drugs capable o...
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The Phage Therapy in the spotlight !

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Bacteriophages: Ancient Predators and the Next Frontier in Medicine In the animated documentary The Deadliest Being on Planet Earth , the Kurzgesagt team delves into the world of bacteriophages—viruses that prey exclusively on bacteria. With vibrant visuals and precise narration, the video introduces viewers to an invisible ecosystem where microscopic hunters orchestrate life-and-death dramas that shape the biosphere. These entities, though virtually unknown to the general public, may soon become central to the future of medicine. At the heart of the video lies a paradox: bacteriophages (or "phages") are among the most abundant biological entities on Earth—outnumbering all other organisms combined—yet their therapeutic potential has been largely sidelined in the antibiotic era. The video outlines the historical trajectory of phage research, spotlighting Félix d’Hérelle’s early 20th-century work and the rise of phage therapy, only to show how it was later eclipsed by the dis...
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Groundbreaking achievement : Phagos raises €25m to end bacterial disease

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 Phagos raises €25m to end bacterial disease  The company holds the first authorization to market personalized veterinary phage-based treatments on EU soil  ● Founded in 2021, Phagos is ushering in a new era in the fight against bacterial disease with bacteriophages, a powerful alternative to antibiotics. Thanks to an unprecedented regulatory breakthrough and a discovery platform combining microbiology and AI, Phagos offers the first phage-based drugs for veterinary use, a market worth tens of billions of dollars. The company plans to expand further as phage therapy becomes accepted in human health.                              ● The funding round was co-led by CapAgro, Hoxton Ventures, CapHorn, and Demeter alongside Acurio Ventures, Citizen Capital, Entrepreneur First, Founders Capital, and Station F.  ● Objectives: deploy veterinary treatments in the field, develop the next generation of pat...
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🌐 PhageAtLabs® — a global interactive mapping of academic laboratories in phage research.

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🌐 PhageAtLabs® — a global interactive mapping of academic laboratories in phage research. Take part in the project here: https://lnkd.in/e-csNChu   Support the project here: https://ko-fi.com/thephagetherapy PhageAtLabs® is currently under active development by The Phage Therapy team, with the aim of launching the platform this summer. At this stage, we are actively collecting information to ensure the platform is as complete and accurate as possible. For this reason, we kindly encourage you to share this form as widely as possible with laboratories, research groups, and colleagues working on bacteriophages that you know. This initiative is dedicated to building an interactive global map of academic laboratories and research groups working on bacteriophages. The goal is to create a structured and continuously updated database that brings together universities, institutes, and research teams involved in phage science worldwide. While similar initiatives exist in the broader ecosy...
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