Posts

Showing posts from September 20, 2026

Nature Medicine Publishes First Detailed Consensus Guideline for Personalized Phage Therapy

-
Image
Personalized bacteriophage therapy has reached an important milestone. On September 21, 2026, Nature Medicine published what its authors describe as the first detailed, consensus-based guideline covering the practical use of personalized phage therapy from the identification of a patient’s bacterial pathogen to phage selection, pharmaceutical preparation, clinical administration, monitoring and long-term follow-up. The document moves beyond general recommendations and attempts to define a workable clinical and pharmaceutical framework for treating difficult bacterial infections when conventional options are insufficient. Figure 1. Overview of the two main approaches to bacteriophage therapy: personalized treatment based on phages matched to an individual patient’s bacterial isolate, and standardized phage products evaluated through clinical trials. The figure also distinguishes phage active pharmaceutical ingredients (APIs) from finished phage therapy medicinal products (PTMPs). Source...
Post a Comment
Read more

HydroPhage Sustains Bacteriophage Delivery for Seven Days and Reduces Drug-Resistant Pseudomonas Wound Infections in Mice

-
Image
A new Nature Communications study addresses a problem that remains poorly defined in bacteriophage therapy: how much phage should be administered, how often it should be given, and whether systemic or local delivery is preferable when treating an established wound infection. Researchers led by Yung-Hao Lin, Tejas Dharmaraj and Qingquan Chen, with Ovijit Chaudhuri and Paul L. Bollyky jointly supervising the work, developed a murine Pseudomonas aeruginosa wound model specifically designed to compare these variables and then used the results to engineer a sustained-release phage hydrogel called HydroPhage. The study was accepted on September 9, 2026. The work involved researchers from Stanford University and Stanford Medicine together with collaborators from University Hospital Münster, Radboud University, New Jersey Institute of Technology and other institutions. Its experimental focus was not simply whether a bacteriophage could kill P. aeruginosa, but how pharmacological variables suc...
Post a Comment
Read more

Most Consulted Articles

Bacteriophages Disarm Inflammation-Associated E. coli Without Erasing the Gut Microbiome in IBD

-
Image
Inflammatory bowel disease is usually described through the language of immune dysregulation, chronic inflammation and genetic susceptibility. Yet an increasingly important part of the disease may lie in a more dynamic layer of biology: not simply which microorganisms inhabit the intestine, but what particular bacterial populations are doing inside it. A new study from McMaster University pushes this idea toward a striking therapeutic possibility. Instead of broadly eliminating bacteria associated with disease, bacteriophages may be used to selectively suppress the bacterial traits that help drive inflammation. McMaster researchers, from left, Kyle Jackson, Zeinab Hosseinidoust and Elena Verdu, have found a way to disarm harmful gut bacteria using precision viruses, opening the door to more personalized treatments for inflammatory bowel disease. (Georgia Kirkos, McMaster University) The work, published in Science Translational Medicine and highlighted on the journal’s cover, emerged...
Read more

History Part 12 : Post-War Stagnation and Phage Therapy’s Marginalization in the West (1945–1980s)

-
Image
Post-War Stagnation and Phage Therapy’s Marginalization in the West (1945–1980s) The period following World War II marked a decisive turning point in the trajectory of phage therapy in Western medicine. Despite the promising results bacteriophages had demonstrated prior to the war as potential antibacterial agents, the decades after 1945 saw a dramatic decline in interest, funding, and scientific engagement with phage therapy in the United States and much of Western Europe. This marginalization can be attributed to a confluence of scientific, sociopolitical, and economic factors that reshaped the landscape of infectious disease treatment and research. Artistic View One of the key contributors to this decline was the overwhelming optimism surrounding the newly discovered class of antibiotics. The post-war pharmaceutical revolution brought forward a series of broad-spectrum antibiotics such as streptomycin, tetracycline, and chloramphenicol, which were viewed as miracle drugs capable o...
Read more

🌐 PhageAtLabs® — a global interactive mapping of academic laboratories in phage research.

-
Image
🌐 PhageAtLabs® — a global interactive mapping of academic laboratories in phage research. Take part in the project here: https://lnkd.in/e-csNChu   Support the project here: https://ko-fi.com/thephagetherapy PhageAtLabs® is currently under active development by The Phage Therapy team, with the aim of launching the platform this summer. At this stage, we are actively collecting information to ensure the platform is as complete and accurate as possible. For this reason, we kindly encourage you to share this form as widely as possible with laboratories, research groups, and colleagues working on bacteriophages that you know. This initiative is dedicated to building an interactive global map of academic laboratories and research groups working on bacteriophages. The goal is to create a structured and continuously updated database that brings together universities, institutes, and research teams involved in phage science worldwide. While similar initiatives exist in the broader ecosy...
Read more

The Phage Therapy in the spotlight !

-
Image
Bacteriophages: Ancient Predators and the Next Frontier in Medicine In the animated documentary The Deadliest Being on Planet Earth , the Kurzgesagt team delves into the world of bacteriophages—viruses that prey exclusively on bacteria. With vibrant visuals and precise narration, the video introduces viewers to an invisible ecosystem where microscopic hunters orchestrate life-and-death dramas that shape the biosphere. These entities, though virtually unknown to the general public, may soon become central to the future of medicine. At the heart of the video lies a paradox: bacteriophages (or "phages") are among the most abundant biological entities on Earth—outnumbering all other organisms combined—yet their therapeutic potential has been largely sidelined in the antibiotic era. The video outlines the historical trajectory of phage research, spotlighting Félix d’Hérelle’s early 20th-century work and the rise of phage therapy, only to show how it was later eclipsed by the dis...
Read more

Groundbreaking achievement : Phagos raises €25m to end bacterial disease

-
Image
 Phagos raises €25m to end bacterial disease  The company holds the first authorization to market personalized veterinary phage-based treatments on EU soil  ● Founded in 2021, Phagos is ushering in a new era in the fight against bacterial disease with bacteriophages, a powerful alternative to antibiotics. Thanks to an unprecedented regulatory breakthrough and a discovery platform combining microbiology and AI, Phagos offers the first phage-based drugs for veterinary use, a market worth tens of billions of dollars. The company plans to expand further as phage therapy becomes accepted in human health.                              ● The funding round was co-led by CapAgro, Hoxton Ventures, CapHorn, and Demeter alongside Acurio Ventures, Citizen Capital, Entrepreneur First, Founders Capital, and Station F.  ● Objectives: deploy veterinary treatments in the field, develop the next generation of pat...
Read more